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KMID : 1100220220210010030
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Dementia and Neurocognitive Disorders
2022 Volume.21 No. 1 p.30 ~ p.41
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Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status
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Mun Ye-Sol
Park Hee-Kyung
Kim Ji-Hee
Yeom Ji-Young
Kim Geon-Ha
Chun Min-Young
Lee Hye-Ah
Yoon Soo-Jin
Park Kyung-Won
Kim Eun-Joo
Yoon Bo-Ra
Jang Jae-Won
Hong Jin-Yong
Choi Seong-Hye
Jeong Jee-Hyang
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Abstract
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Background and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI.
Methods: We enrolled a cohort of 3,038 subjects with MCI aged 65?90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders.
Results: Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone.
Conclusions: Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.
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KEYWORD
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Body Mass Index, Apolipoprotein E, Cognitive Function, Mild Cognitive Impairment
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